Exploiting the neonatal crystallizable fragment receptor to treat ...
In this review, we summarize what is known about FcRn and its function within the kidney. We also discuss how FcRn has been used for therapeutic benefit, including how newer FcRn inhibiting agents …
Journal of the American Society of Nephrology
Diabetic kidney disease is the leading cause for the development of CKD. GWAS studies presented a strong association between the neonatal Fc receptor (FcRn) and high fructosamin levels in diabetes …
Megalin Orchestrates FcRn Endocytosis and Trafficking - MDPI
Dec 22, 2022 · The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine.
Exploiting the neonatal crystallizable fragment ... - Kidney International
Jun 9, 2023 · In this review, we will describe the structure and function of FcRn. We will focus on this receptor’s role in the kidney and describe how modulation of FcRn is being used to create therapies …
Presence and possible impact of Fcγ receptors on resident kidney cells ...
Jun 30, 2022 · Investigations of FcγR expression in podocytes appear to be of great clinical importance. The present review discusses the latest literature on FcγRs in kidney cells (especially podocytes), …
Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
The widely distributed neonatal Fc receptor (FcRn) contributes to maintaining serum levels of albumin and IgG in adults. In the kidney, FcRn is expressed on the podocytes and the brush border of the …
The Neonatal Fc Receptor (FcRn): A Misnomer? - Frontiers
Jul 10, 2019 · FcRn in the kidney is important also for albumin homeostasis, as mice lacking FcRn have reduced serum levels of albumin, which can be rescued by transplantation of an FcRn expressing …
In this review, we will describe the structure and function of FcRn. We will focus on this receptor’s role in the kidney and describe how modulation of FcRn is being used to create therapies with the potential …
Albumin influences leucocyte FcRn expression in the early days of ...
Feb 12, 2024 · Knowing that autophagy is strongly involved in the development of reperfusion injury in kidney transplantation and that albuminemia is transiently decreased in the first 2 weeks after …
Exploiting the neonatal crystallizable fragment receptor to treat ...
Jan 1, 2024 · In this review, we will describe the structure and function of FcRn. We will focus on this receptor’s role in the kidney and describe how modulation of FcRn is being used to create therapies …