The Arizona Cardinals, led by quarterback Jacoby Brissett, face the Houston Texans, led by quarterback C.J. Stroud, on Sunday, Dec. 14, 2025 at NRG Stadium in Houston, Texas.

What's the Arizona Cardinals vs Houston Texans score? Follow our live score updates for latest news, highlights, analysis from NFL Week 15 game.

The Arizona Cardinals' woes vs. the Houston Texans get worse after Bam Knight suffered an injury that led to him being carted off the field.

C.J. Stroud threw for 260 yards and three touchdowns and the Houston Texans jumped out to a big early lead and cruised to a 40-20 victory over the slumping Arizona Cardinals.

Harris and Hill are former draft picks of the Texans from the 2024 and 2023 cycles, respectively. Arnette was a first-round pick by the Las Vegas Raiders in 2020, taken 19th overall. He has bounced back and forth between the Texans’ roster, practice squad, and free agency since initially signing during the offseason.

The Texans took control early and were never seriously threatened as they continued to solidify their hold on an AFC playoff spot.

The Arizona Cardinals again came out flat -- and it cost them their Week 15 matchup against the Houston Texans.

Practice-squad wide receiver Jalen Brooks, who has been with the team since Oct. 30, fumbled the ensuing kickoff and the Texans recovered at the 22-yard line. One bright spot was the defense stopped the Texans after one first down and they had to settle for a field goal. Still, it was 10-0 after only 3:58 had come off the clock.

The Arizona Cardinals have lost their past five games and 10 of 11. Now, they go up against a Houston Texans team that has the NFL's best defense.